PXN
Description
The PXN (paxillin) is a protein-coding gene located on chromosome 12.
PXN encodes Paxillin, a protein crucial for cell adhesion. It is found at focal adhesions of non-muscle cells and at costameres of striated muscle cells, linking cells to the extracellular matrix. Paxillin is a 64.5 kDa protein with 591 amino acids. Its C-terminal region contains four LIM domains, important for targeting to focal adhesions and interacting with proteins like the protein tyrosine phosphatase-PEST, tubulin. The N-terminal region has five LD motifs that interact with pp125FAK and vinculin, and a proline-rich domain for Src-SH3 binding. Mutations in PXN and abnormal paxillin expression are implicated in cancer development.
PXN is a cytoskeletal protein that plays a crucial role in connecting the actin cytoskeleton to the cell membrane at focal adhesions, the points where cells attach to the extracellular matrix. It recruits other proteins, such as TRIM15, to these sites, contributing to the overall structure and function of focal adhesions.
PXN is also known as -.
