PVT1
Description
The PVT1 (Pvt1 oncogene) is a ncRNA gene located on chromosome 8.
PVT1, also known as Plasmacytoma Variant Translocation 1, is a long non-coding RNA gene. It was first identified in mice as a breakpoint site in chromosome 6;15 translocations associated with murine plasmacytomas. The equivalent translocation in humans is t(2;8), associated with a rare variant of Burkitt's lymphoma. PVT1's transcription is regulated by Myc. Overexpression of PVT1 can contribute to tumor development in several ways: 1) Rearrangements of DNA through the fusion of PVT1 and oncogene or tumor suppressor genes can lead to dysregulation of these genes, eventually causing tumorigenesis. 2) Expression of PVT1-encoded miRNAs can downregulate tumor suppressor genes, leading to tumorigenesis. 3) Increased interaction of MYC with PVT1 can also contribute to tumor development.
PVT1 is also known as LINC00079, MIR1204HG, NCRNA00079, TP53LC09, onco-lncRNA-100.
Associated Diseases
- cancer
- nonpapillary renal cell carcinoma
- breast cancer
- Miyoshi myopathy
- achalasia-alacrima syndrome
- urinary bladder carcinoma
- pachyonychia congenita
