PTP4A1

Description

The PTP4A1 (protein tyrosine phosphatase 4A1) is a protein-coding gene located on chromosome 6.

Protein tyrosine phosphatase type IVA 1 is an enzyme that in humans is encoded by the PTP4A1 gene. This protein belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein but may primarily associate with the plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells.

PTP4A1 has been shown to interact with ATF7.

PTP4A1 is also known as HH72, PRL-1, PRL1, PTP(CAAX1), PTPCAAX1.

Associated Diseases

WES Whole Exome Sequencing