PTGES2

Description

The PTGES2 (prostaglandin E synthase 2) is a protein-coding gene located on chromosome 9.

PTGES2, also known as Microsomal prostaglandin E synthase-2 (mPGES-2) or Prostaglandin E synthase 2, is a human gene located on chromosome 9. It encodes a membrane-associated enzyme that catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also activates transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants exist for this gene. PTGES2 is a dimer with a structure featuring two hydrophobic pockets connected to form a V shape that binds to the anti-inflammatory drug indomethacin (IMN). The gene contains 10 exons and encodes a 33-kDa protein targeted to the Golgi apparatus and mitochondrion.

PTGES2 is an isomerase that catalyzes the conversion of PGH2 into PGE2 in vitro. However, its biological function and GSH-dependent properties are still debated. In vivo, PTGES2 may form a complex with GSH and heme, potentially leading to the degradation of PGH2 into HHT and MDA rather than PGE2 synthesis.

PTGES2 is also known as C9orf15, GBF-1, GBF1, PGES2, mPGES-2.

Associated Diseases

• low grade glioma
• acute kidney failure
• lymphatic malformation 3
• isolated asymptomatic elevation of creatine phosphokinase
• cryohydrocytosis
• Lipedema
• pentosuria
• thrombocythemia 2
• hemolytic anemia due to erythrocyte adenosine deaminase overproduction
• familial isolated congenital asplenia
• type 2 diabetes mellitus
• lymphatic malformation 8
• elliptocytosis 2
• dehydrated hereditary stomatocytosis
• Rh deficiency syndrome
• immunodeficiency 69
• thrombocytopenia 4