PTGER2
Description
The PTGER2 (prostaglandin E receptor 2) is a protein-coding gene located on chromosome 14.
The PTGER2 gene encodes for the Prostaglandin E2 receptor 2 (EP2), one of four identified EP receptors that bind and mediate cellular responses to PGE2. It is located on chromosome 14 at position p22.1 and contains 2 introns and 3 exons. The gene codes for a G protein coupled receptor (GPCR) belonging to the rhodopsin-like receptor family. EP2 is widely distributed in humans, with its protein expressed in tissues including the small intestine, lung, kidney, thymus, uterus, brain, cornea, and airway smooth muscle cells. Its mRNA is expressed in gingival fibroblasts, monocyte-derived dendritic cells, aorta, corpus cavernosum, articular cartilage, and airway epithelial cells. In rats, the receptor protein and/or mRNA has been found in lung, spleen, intestine, skin, kidney, liver, long bones, and throughout the brain and central nervous system. EP2 expression is reduced in fibroblasts from the lungs of mice with bleomycin-induced pulmonary fibrosis and humans with Idiopathic pulmonary fibrosis, associated with hypermethylation of CpG dinucleotide sites in the upstream region of the PTGER2 gene. This suggests that EP2 expression is regulated by methylation.
PTGER2 is also known as EP2.
