PTGER1
Description
The PTGER1 (prostaglandin E receptor 1) is a protein-coding gene located on chromosome 19.
The PTGER1 gene encodes the Prostaglandin E2 receptor EP1 subtype (also known as Prostanoid EP1 receptor, PGE2 receptor EP1 subtype), a 42 kDa protein that is a member of the rhodopsin-like G protein-coupled receptor family. It is one of four known EP receptors (EP1, EP2, EP3, and EP4), all of which bind to and mediate cellular responses primarily to prostaglandin E2 (PGE2). PTGER1 is located on chromosome 19p13.12 and contains 2 introns and 3 exons. While expression of PTGER1 has been observed in various tissues in animal models, including the kidney, lung, stomach, thalamus, and dorsal root ganglia neurons, in humans, its expression appears more limited, having been detected in human mast cells, pulmonary veins, keratinocytes, myometrium, and colon smooth muscle.
PTGER1 is also known as EP1.
Associated Diseases
- acute kidney failure
- chronic renal failure syndrome
- thrombotic disease
- prostate cancer
- urolithiasis
- benign muscle neoplasm
