PTGDR2

Description

The PTGDR2 (prostaglandin D2 receptor 2) is a protein-coding gene located on chromosome 11.

The PTGDR2 gene, located on human chromosome 11 at position q12.2, encodes the Prostaglandin D2 receptor 2 (DP2), also known as CRTH2 or CD294. DP2 is a member of the prostaglandin receptor family, which bind and respond to various prostaglandins. Along with Prostaglandin DP1 receptor, DP2 is a receptor for prostaglandin D2 (PGD2). Activation of DP2 by PGD2 or other cognate receptor ligands has been associated with certain physiological and pathological responses, particularly those associated with allergy and inflammation, in animal models and certain human diseases. The PTGDR2 gene consists of two introns and three exons, coding for a G protein coupled receptor (GPCR) composed of 472 amino acids. DP2 is related to members of the chemotactic factor class of GPCRs, sharing an amino acid sequence identity of 29% with the C5a receptor, Formyl peptide receptor 1, and Formyl peptide receptor 2 receptors. DP2 has little or no such amino acid sequence relationship to the eight other Prostanoid receptors.

The PTGDR2 gene encodes the Prostaglandin D2 receptor 2 (DP2), also known as CRTH2, a G protein-coupled receptor (GPCR) for prostaglandin D2 (PGD2). Activation of DP2 by PGD2 is linked to immune regulation and allergic/inflammatory responses. DP2 signaling involves G(i)-protein coupling, which leads to decreased cAMP levels and Ca(2+) mobilization, and is sensitive to pertussis toxin. The receptor also utilizes PI3K signaling. Internalization of DP2 is induced by PGD2 and is regulated by kinases such as PKC, PKA, GRK2, GPRK5/GRK5 and GRK6.

PTGDR2 is also known as CD294, CRTH2, DL1R, DP2, GPR44.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing