PSME1

Description

The PSME1 (proteasome activator subunit 1) is a protein-coding gene located on chromosome 14.

Proteasome activator complex subunit 1 is a protein encoded by the PSME1 gene in humans. It is part of the 26S proteasome, a large protein complex responsible for breaking down proteins in cells. The 26S proteasome has two main parts: the 20S core and the 19S regulator. The 20S core breaks down proteins, while the 19S regulator controls which proteins are targeted for degradation. PSME1 is a subunit of the 11S regulator (also called PA28), which replaces the 19S regulator in a specialized form of the proteasome called the immunoproteasome. The immunoproteasome is important for processing proteins that are presented by the immune system. PSME1 is one of two subunits of the 11S regulator that is induced by interferon-gamma, a signaling molecule involved in immune responses.

PSME1 is also known as HEL-S-129m, IFI5111, PA28A, PA28alpha, REGalpha.

Associated Diseases

WES Whole Exome Sequencing