PSMD8
Description
The PSMD8 (proteasome 26S subunit, non-ATPase 8) is a protein-coding gene located on chromosome 19.
PSMD8, or 26S proteasome non-ATPase regulatory subunit 8, is an enzyme encoded by the PSMD8 gene. It is a component of the 26S proteasome, a complex involved in protein degradation. The 26S proteasome has two parts: a 20S core and a 19S regulator. PSMD8 is part of the 19S regulator, specifically the lid portion. The proteasome is important for removing damaged or unneeded proteins, contributing to processes like cell cycle control and DNA repair. A variation of the proteasome, the immunoproteasome, is involved in the immune system. A pseudogene for PSMD8 exists on chromosome 1. The proteasome and its components are important in disease understanding and as potential drug targets.
PSMD8 is part of the 26S proteasome, a multi-protein complex that breaks down ubiquitinated proteins using ATP. The proteasome maintains protein balance by removing misfolded or damaged proteins, preventing cellular dysfunction, and removing proteins no longer needed. This process is essential for numerous cellular functions, including cell cycle progression, apoptosis, and DNA damage repair.
PSMD8 is also known as HEL-S-91n, HIP6, HYPF, Nin1p, Rpn12, S14, p31.
