PSMD3
Description
The PSMD3 (proteasome 26S subunit, non-ATPase 3) is a protein-coding gene located on chromosome 17.
PSMD3, also known as 26S proteasome non-ATPase regulatory subunit 3, is an enzyme essential for protein breakdown in human cells. It is part of the 26S proteasome, a complex that degrades proteins marked with ubiquitin tags. The proteasome comprises a core (20S) and a regulatory (19S) subunit. PSMD3 is a non-ATPase subunit of the 19S lid, which recognizes and directs proteins for degradation. The 26S proteasome plays a vital role in maintaining cellular function by eliminating damaged or unwanted proteins. Disruptions to the proteasome's function can be linked to various diseases, making it a target for potential therapies. Furthermore, understanding the proteasome's role in health and disease could lead to the development of new diagnostic tools.
PSMD3 is part of the 26S proteasome, a complex that breaks down proteins marked for destruction by attaching ubiquitin molecules. This process, fueled by ATP, maintains cellular health by eliminating misfolded or damaged proteins, as well as those no longer needed. This crucial function underpins a range of cellular activities including cell growth, programmed cell death, and DNA repair.
PSMD3 is also known as P58, RPN3, S3, TSTA2.
