PSMD2
Description
The PSMD2 (proteasome 26S subunit ubiquitin receptor, non-ATPase 2) is a protein-coding gene located on chromosome 3.
PSMD2, also known as 26S Proteasome Non-ATPase Regulatory Subunit 2, is an enzyme encoded by the PSMD2 gene in humans. It is a non-ATPase subunit of the 19S regulator base, involved in substrate recognition and binding. Additionally, it is a non-ATPase subunit of the 19S regulator lid and may participate in the TNF signaling pathway through its interaction with the tumor necrosis factor type 1 receptor. The PSMD2 gene has 23 exons and is located on chromosome band 3q27.1. The protein is 100 kDa in size and consists of 909 amino acids, with a theoretical pI of 5.10. Alternative splicing generates two expression isoforms, one lacking amino acids 1-130 and the other lacking 1-163. The 26S proteasome complex comprises a 20S core particle (CP) and one or two 19S regulatory particles (RP) located on either side of the barrel-shaped 20S. The CP and RPs have distinct structural characteristics and biological functions.
PSMD2 is a component of the 26S proteasome, a multiprotein complex crucial for the ATP-dependent degradation of ubiquitinated proteins. This complex maintains protein homeostasis by eliminating misfolded or damaged proteins, preventing cellular dysfunction, and removing proteins that are no longer needed. Consequently, the proteasome plays a vital role in a wide range of cellular processes including cell cycle progression, apoptosis, and DNA damage repair.
PSMD2 is also known as P97, RPN1, S2, TRAP2.
