PSMD13
Description
The PSMD13 (proteasome 26S subunit, non-ATPase 13) is a protein-coding gene located on chromosome 11.
PSMD13 (26S proteasome non-ATPase regulatory subunit 13) is a gene that encodes an enzyme involved in protein degradation. It is part of the 26S proteasome, a complex structure composed of two parts: a 20S core and a 19S regulator. The 20S core breaks down proteins, while the 19S regulator controls this process. PSMD13 is a non-ATPase subunit of the 19S regulator, helping to regulate the proteasome's activity. The proteasome plays a crucial role in removing damaged or unnecessary proteins, maintaining cell function. Dysfunctional proteasomes can contribute to various diseases, making them a target for drug development. The proteasome is also being explored for potential diagnostic applications.
PSMD13, also known as RPN9, is a subunit of the 26S proteasome, a multiprotein complex that degrades ubiquitinated proteins. This process is crucial for maintaining protein homeostasis by removing damaged or misfolded proteins, and those that are no longer needed. The proteasome's activity is essential for various cellular processes, including cell cycle progression, apoptosis, and DNA damage repair.
PSMD13 is also known as HSPC027, Rpn9, S11, p40.5.
