PSMD12
Description
The PSMD12 (proteasome 26S subunit, non-ATPase 12) is a protein-coding gene located on chromosome 17.
PSMD12, also known as 26S proteasome non-ATPase regulatory subunit 12, is an enzyme encoded by the PSMD12 gene in humans. It is a component of the 26S proteasome, a large protein complex responsible for degrading proteins. The proteasome is crucial for maintaining protein homeostasis and regulating various cellular processes, such as cell cycle progression, apoptosis, and DNA damage repair. The 26S proteasome consists of two parts: a 20S core particle and a 19S regulator. PSMD12 is a non-ATPase subunit of the 19S regulator, which helps to regulate the activity of the proteasome. Mutations in PSMD12 have been linked to various diseases, and the proteasome is a potential target for drug development.
PSMD12 is a component of the 26S proteasome, a large protein complex responsible for the breakdown of ubiquitinated proteins. This process is crucial for maintaining protein homeostasis, removing damaged or misfolded proteins, and regulating the levels of proteins that are no longer needed. The 26S proteasome plays a vital role in many cellular processes, including cell cycle control, programmed cell death (apoptosis), and DNA damage repair.
PSMD12 is also known as Rpn5, STISS, p55.
