PSMD11
Description
The PSMD11 (proteasome 26S subunit, non-ATPase 11) is a protein-coding gene located on chromosome 17.
PSMD11, also known as 26S proteasome non-ATPase regulatory subunit 11, is an enzyme encoded by the PSMD11 gene. It is a subunit of the 26S proteasome, a complex responsible for protein degradation. The proteasome consists of a 20S core and a 19S regulator. PSMD11 is a non-ATPase subunit of the 19S regulator. The proteasome plays a vital role in maintaining cellular function by removing damaged or misfolded proteins. Dysfunction of the proteasome can be associated with various diseases and is a target for drug development.
PSMD11, also known as RPN6, S9, or p44.5, is a subunit of the 26S proteasome, a multi-protein complex crucial for the degradation of ubiquitinated proteins. The proteasome maintains protein homeostasis by removing misfolded or damaged proteins, essential for proper cellular function. PSMD11 is involved in the assembly of the proteasome, and its high expression in embryonic stem cells promotes enhanced assembly, resulting in increased proteasome activity. This contributes to various cellular processes, including cell cycle progression, apoptosis, and DNA damage repair.
PSMD11 is also known as Rpn6, S9, p44.5.
