PSMD10
Description
The PSMD10 (proteasome 26S subunit, non-ATPase 10) is a protein-coding gene located on chromosome X.
PSMD10, also known as Gankyrin, is a protein that plays a crucial role in regulating the cell cycle and cellular processes. It is a component of the 19S regulatory cap of the proteasome, a complex responsible for protein degradation. PSMD10 interacts with various proteins, including CDK4, MDM2, and p53, influencing cell cycle regulation and tumor suppression. It is overexpressed in certain cancers, suggesting its involvement in tumorigenesis.
PSMD10 acts as a chaperone in the assembly of the 26S proteasome, particularly in the formation of the PA700/19S regulatory complex (RC). It is part of an intermediate module (PSMD10:PSMC4:PSMC5:PAAF1) during the initial assembly of the base subcomplex, which likely interacts with another module (PSMD5:PSMC2:PSMC1:PSMD2). Beyond its role in the proteasome, PSMD10 regulates EGF-induced AKT activation by inhibiting the RHOA/ROCK/PTEN pathway, ultimately leading to prolonged AKT activation. It plays a significant role in RAS-induced tumorigenesis.
PSMD10 is also known as dJ889N15.2, p28, p28(GANK).
