PSMC6

Description

The PSMC6 (proteasome 26S subunit, ATPase 6) is a protein-coding gene located on chromosome 14.

PSMC6, also known as 26S proteasome regulatory subunit S10B or 26S proteasome AAA-ATPase subunit Rpt4, is an enzyme encoded by the PSMC6 gene in humans. It is one of the 19 essential subunits of the 19S proteasome complex, specifically belonging to the base subcomplex of the 19S regulatory particle. This protein is part of the triple-A family of ATPases, known for their chaperone-like activity. The PSMC6 gene is located on chromosome 14q22.1 and contains 15 exons. The human PSMC6 protein is 44kDa in size and composed of 389 amino acids, with a calculated theoretical pI of 7.09. The 26S proteasome complex is formed by a 20S core particle (CP) and one or two 19S regulatory particles (RP) attached to the CP. The 20S CP possesses three types of proteolytic activities: caspase-like, trypsin-like, and chymotrypsin-like, which are located within a chamber formed by four stacked rings of 20S subunits.

PSMC6 is a component of the 26S proteasome, a complex responsible for degrading ubiquitinated proteins. This process is ATP-dependent and essential for maintaining protein homeostasis by removing damaged or misfolded proteins. The proteasome plays a crucial role in various cellular processes, including cell cycle progression, apoptosis, and DNA damage repair. PSMC6, as part of the heterohexameric ring of AAA ATPases, unfolds ubiquitinated target proteins before they are translocated into the proteolytic chamber for degradation.

PSMC6 is also known as RPT5, SUG2, p42.

Associated Diseases

WES Whole Exome Sequencing