PSMC5
Description
The PSMC5 (proteasome 26S subunit, ATPase 5) is a protein-coding gene located on chromosome 17.
PSMC5, also known as 26S proteasome regulatory subunit 8, is an enzyme encoded by the human PSMC5 gene. It is one of the 19 essential subunits of the 19S proteasome complex, which is part of the larger 26S proteasome complex. This complex plays a critical role in protein degradation within cells. PSMC5 is an ATPase subunit belonging to the triple-A family, known for its chaperone-like activity. It participates in the proteasome's function and may also be involved in transcriptional regulation due to its interactions with the thyroid hormone receptor and retinoid X receptor-alpha. The human PSMC5 gene has 13 exons and is located on chromosome band 17q23.3. The PSMC5 protein is 45.6kDa in size, composed of 406 amino acids, and has a calculated theoretical pI of 8.23. The 26S proteasome complex consists of a 20S core particle (CP) and one or two 19S regulatory particles (RP). The CP provides the proteolytic activity, while the RPs regulate the process. PSMC5 is part of the base sub complex of the 19S regulatory particle, which forms the interface with the 20S core particle.
PSMC5 is part of the 26S proteasome, a complex responsible for degrading ubiquitinated proteins. This process is crucial for maintaining protein homeostasis by removing damaged or misfolded proteins. The proteasome plays a vital role in cellular processes such as cell cycle progression, apoptosis, and DNA repair. PSMC5 belongs to a ring of AAA proteins within the proteasome, unfolding ubiquitinated targets and moving them into the proteolytic chamber for breakdown into peptides.
PSMC5 is also known as RPT6, S8, SUG-1, SUG1, TBP10, TRIP1, p45, p45/SUG.
