PSMC2

Description

The PSMC2 (proteasome 26S subunit, ATPase 2) is a protein-coding gene located on chromosome 7.

PSMC2, also known as 26S proteasome regulatory subunit 7, is an enzyme encoded by the PSMC2 gene in humans. It is one of the 19 essential subunits of the 19S proteasome complex, a key component of the 26S proteasome involved in protein degradation. PSMC2 is an ATPase subunit belonging to the triple-A family, known for its chaperone-like activity. It interacts with several basal transcription factors, suggesting a role in regulating transcription in addition to its proteasome function. PSMC2 may also compete with PSMC3 for binding to the HIV tat protein, potentially regulating the interaction between the viral protein and the transcription complex. The PSMC2 gene has 13 exons and is located on chromosome band 7q22.1-q22.3. The human PSMC2 protein is 48.6kDa in size, composed of 433 amino acids, and has a calculated theoretical pI of 5.71. Alternative splicing generates an isoform lacking amino acids 1-137. The 26S proteasome consists of a 20S core particle (CP) and one or two 19S regulatory particles (RP), each with distinct structures and functions. The 19S regulatory particle is further divided into a lid and a base. PSMC2 is part of the base, along with other ATPases and non-ATPase subunits.

PSMC2 is a component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in maintaining protein homeostasis by removing misfolded or damaged proteins and proteins whose functions are no longer required. This process is essential for various cellular processes, including cell cycle progression, apoptosis, and DNA damage repair. PSMC2 is part of the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfold ubiquitinated target proteins, concurrently translocating them into a proteolytic chamber for degradation into peptides.

PSMC2 is also known as MSS1, Nbla10058, RPT1, S7.

Associated Diseases

WES Whole Exome Sequencing