PSMB11
Description
The PSMB11 (proteasome subunit beta 11) is a protein-coding gene located on chromosome 14.
PSMB11 is a subunit of the proteasome, a protein complex that breaks down proteins. It specifically affects the proteasome's ability to cleave peptides with certain amino acids (Arg, Phe, Tyr, Leu, and Glu) near the cleavage site. PSMB11 is involved in the development of CD8-positive T cells, a type of immune cell that plays a crucial role in fighting infections.
PSMB11 is also known as BETA5T.
Associated Diseases
- endometrial cancer
- anaplastic ependymoma
- common variable immunodeficiency
- combined immunodeficiency with skin granulomas
- immunodeficiency 18
- severe combined immunodeficiency due to IKK2 deficiency
