PRSS8

Description

The PRSS8 (serine protease 8) is a protein-coding gene located on chromosome 16.

PRSS8 encodes a trypsinogen, a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is found in seminal fluid. It is cleaved to produce a light and heavy chain, linked by a disulfide bond. PRSS8 is active on peptide linkages involving the carboxyl group of lysine or arginine. It plays a role in epithelial sodium channel regulation and may contribute to various tissue functions involving sodium channels. High prostasin plasma levels might be linked to an increased risk of diabetes and cancer death, particularly in individuals with high blood sugar.

PRSS8 possesses a trypsin-like cleavage specificity, showing a preference for poly-basic substrates. It activates epithelial sodium channel (ENaC) activity by cleaving and activating the gamma subunits (SCNN1G).

PRSS8 is also known as CAP1, PROSTASIN.

Associated Diseases

• endometrial cancer
• cancer
• hypotrichosis simplex
• uncombable hair syndrome
• wooly hair, autosomal recessive 3
• hypotrichosis 4
• ringed hair disease
• trichodysplasia-xeroderma syndrome
• Leukomelanoderma-infantilism-intellectual disability-hypodontia-hypotrichosis syndrome
• pure hair and nail ectodermal dysplasia
• hidrotic ectodermal dysplasia, Christianson-Fourie type
• tarsal-carpal coalition syndrome
• atrichia with papular lesions
• Graham Little-Piccardi-Lassueur syndrome