PRSS23
PRSS23 Gene: A Comprehensive Guide
Description
The PRSS23 gene, located on chromosome 11p15.5, encodes a serine protease called pancreatic trypsin-like enzyme 1 (PRSS1). This enzyme plays a vital role in the digestive system, specifically the pancreas. It aids in the breakdown of proteins during digestion.
Associated Diseases
Mutations in the PRSS23 gene have been associated with several medical conditions, including:
- Hereditary pancreatitis: This condition involves chronic inflammation of the pancreas, leading to abdominal pain, nausea, and vomiting. Mutations in PRSS23 are a common cause of hereditary pancreatitis.
- Idiopathic pancreatitis: In some cases of pancreatitis, no underlying cause can be identified. However, research suggests that PRSS23 mutations may be involved in a significant proportion of these cases.
- Pancreatic cancer: Studies have shown an association between PRSS23 mutations and an increased risk of pancreatic cancer.
Did you Know ?
Approximately 1 in 200 people in the United States carry a mutation in the PRSS23 gene. This makes it one of the most common genetic risk factors for pancreatitis.
