PRR26
PRR26 Gene: A Comprehensive Guide
Description
The PRR26 gene, also known as the proline-rich protein 26 gene, encodes a protein involved in various cellular processes, including cell adhesion, migration, and differentiation. It is located on chromosome 14q11.2 and consists of 10 exons.
The PRR26 protein is composed of several domains, including a proline-rich domain, a glycine-rich domain, and a signal peptide. It interacts with multiple proteins and signaling pathways, playing a critical role in the regulation of cell behavior and tissue development.
Associated Diseases
Mutations in the PRR26 gene have been linked to several diseases and disorders, including:
- Leukemia: PRR26 overexpression is associated with the development of acute myeloid leukemia (AML) and chronic myeloid leukemia (CML).
- Congenital malformations: Mutations in PRR26 have been implicated in a range of congenital malformations, such as cleft lip and palate, heart defects, and limb abnormalities.
- Autoimmune diseases: PRR26 deficiency has been linked to an increased risk of autoimmune diseases, such as lupus and rheumatoid arthritis.
Did you Know ?
- PRR26 overexpression is found in approximately 20% of AML cases.
