PROX1
Description
The PROX1 (prospero homeobox 1) is a protein-coding gene located on chromosome 1.
Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene. The Prox1 gene is critical for the development of multiple tissues. Prox1 activity is necessary and sufficient to specify a lymphatic endothelial cell fate in endothelial progenitors located in the embryonic veins. PROX1 has been shown to interact with EP300. PROX1 is produced primarily in the dentate gyrus in the mouse, and in the dentate gyrus and white matter in humans. Gene expression data for mouse, human and macaque from the Allen Brain Atlases can be found here. PROX1 is used as a marker for lymphatic endothelium in biopsy samples. PROX2 is a homologous gene.
PROX1 acts as a transcription factor that plays a crucial role in regulating developmental processes, including cell fate determination, gene expression, and progenitor cell maintenance in various organs. It is essential for embryonic development, particularly in neurogenesis, and the formation of the heart, eye lens, liver, pancreas, and lymphatic system. PROX1 is also involved in regulating the circadian rhythm. Its function involves repressing the transcription of the retinoid-related orphan receptor RORG, inhibiting the transcriptional activation activities of RORA and RORG, and suppressing the expression of RORA/G-target genes. These target genes include core clock components (BMAL1, NPAS2, CRY1) and metabolic genes (AVPR1A, ELOVL3).
PROX1 is also known as -.
