PROB1
Description
The PROB1 (proline rich basic protein 1) is a protein-coding gene located on chromosome 5.
PROB1, also known as C5orf65, is a protein encoded by the PROB1 gene located on human chromosome 5. The gene is 3251 bp long and contains a single exon. PROB1 is expressed in 89 types of tissue in the human body, with highest expression in the skeletal muscle of the leg and cardiac muscle of the heart. While mRNA expression is somewhat ubiquitous and was also elevated in the spinal cord, cerebrum, and lymphocytes, measurable protein expression was only recorded in cardiac and skeletal muscle. PROB1 is composed of 1015 amino acids. It contains two proline-rich regions, which compose the majority of the protein, and a domain of unknown function (DUF). Predicted secondary structures for PROB1 reveal that the protein is mostly composed of random coils, with a small percentage of alpha helices and beta sheets present. This is likely due to the properties of proline; its large size, ring structure, and confined phi angle cause it to disrupt secondary structure formation.
PROB1, also known as C5orf65, is a protein with a possible role in skeletal and cardiac muscle function. While its mRNA is expressed in a wide range of tissues, measurable protein expression is primarily observed in these muscle types. The protein contains two proline-rich regions, which are likely responsible for its disordered structure, as well as a domain of unknown function (DUF). The protein's structure is predominantly composed of random coils, with a small proportion of alpha helices and beta sheets.
PROB1 is also known as C5orf65.
