PRM1
Description
The PRM1 (protamine 1) is a protein-coding gene located on chromosome 16.
Protamine 1 is a protein that in humans is encoded by the PRM1 gene.
Protamines, including protamine 1, replace histones in the sperm's chromatin during the haploid stage of spermatogenesis. This replacement leads to the compaction of sperm DNA, resulting in a highly condensed, stable, and inactive complex.
PRM1 is also known as CT94.1, P1.
Associated Diseases
- male infertility with teratozoospermia due to single gene mutation
- multiple sclerosis
- spermatogenic failure 72
- spermatogenic failure 18
- spermatogenic failure 27
- spermatogenic failure 46
- spermatogenic failure 43
- spermatogenic failure 45
- spermatogenic failure 19
