PRLHR
PRLHR Gene: Unraveling Its Role in Development and Disease
Description
The PRLHR gene, also known as the prolactin receptor gene, encodes the receptor for prolactin, a hormone produced by the pituitary gland. Prolactin plays a crucial role in various physiological processes, particularly during pregnancy and lactation.
Associated Diseases
Defects in the PRLHR gene have been linked to a range of disorders, including:
- Hyperprolactinemia: Excessive prolactin production, often caused by a pituitary tumor or medication side effects.
- Infertility: PRLHR mutations can disrupt prolactin signaling, affecting ovulation and sperm production.
- Galactorrhea: Inappropriate milk production in non-puerperal women.
- Congenital adrenal hyperplasia (CAH): A rare condition caused by impaired cortisol synthesis, in which PRLHR mutations can exacerbate symptoms.
Did you Know ?
Approximately 1 in 250 women have hyperprolactinemia, highlighting the prevalence of PRLHR-associated disorders.
