PRICKLE3
Description
The PRICKLE3 (prickle planar cell polarity protein 3) is a protein-coding gene located on chromosome X.
PRICKLE3 is a protein involved in the planar cell polarity (PCP) pathway. This pathway is crucial for the coordinated alignment and orientation of cells during developmental processes like gastrulation and neurulation. PRICKLE3 functions as part of the core PCP module, contributing to the formation of complexes that localize to opposite sides of a cell and interact with neighboring cells, maintaining the overall PCP. PRICKLE3 also plays a role in the organization of the basal body, which is involved in the growth and positioning of cilia. Interestingly, PRICKLE3 is also essential for the assembly, stability, and function of mitochondrial membrane ATP synthase, a vital enzyme for energy production within cells.
PRICKLE3 participates in the planar cell polarity (PCP) pathway, which is crucial for the alignment and orientation of cells during development. It functions as part of the core PCP module, where it helps establish distinct complexes that segregate to opposite sides of a cell. These complexes interact with their counterparts in neighboring cells, playing a vital role in cell-cell communication. Additionally, PRICKLE3 influences the organization of the basal body, a structure essential for the growth and positioning of cilia. Furthermore, PRICKLE3 has been shown to be necessary for the proper assembly, stability, and function of mitochondrial ATP synthase, a crucial enzyme involved in energy production.
PRICKLE3 is also known as LMO6, LOAM, LOAS, Pk3.
