PRDX6

Description

The PRDX6 (peroxiredoxin 6) is a protein-coding gene located on chromosome 1.

PRDX6 is a protein encoded by the PRDX6 gene in humans. It belongs to the peroxiredoxin family of antioxidant enzymes. It is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.

PRDX6 is a thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols. It can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. PRDX6 also has phospholipase activity and can either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. PRDX6 plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis. It exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC). PRDX6 shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate. {ECO:0000269|PubMed:10893423, ECO:0000269|PubMed:26830860, ECO:0000269|PubMed:9497358}

PRDX6 is also known as 1-Cys, AOP2, HEL-S-128m, LPCAT-5, NSGPx, PRX, aiPLA2, p29.

Associated Diseases

WES Whole Exome Sequencing