PRCP
Description
The PRCP (prolylcarboxypeptidase) is a protein-coding gene located on chromosome 11.
PRCP (Lysosomal Pro-X carboxypeptidase) is an enzyme encoded by the human PRCP gene. It functions as a lysosomal prolylcarboxypeptidase, specifically cleaving C-terminal amino acids linked to proline in peptides like angiotensin II, III, and des-Arg9-bradykinin. This cleavage predominantly takes place at acidic pH, although the enzyme retains some activity with certain substrates at neutral pH. PRCP has been identified as an activator of cell matrix-associated prekallikrein. Given the role of angiotensin II, one of PRCP's substrates, in regulating blood pressure and electrolyte balance, PRCP may be associated with essential hypertension. Multiple transcript variants have been observed, encoding distinct isoforms.
PRCP cleaves C-terminal amino acids linked to proline in peptides like angiotensin II, III, and des-Arg9-bradykinin. This cleavage primarily occurs at acidic pH, but the enzyme retains some activity with certain substrates at neutral pH.
PRCP is also known as HUMPCP, PCP.
