PPP6C
Description
The PPP6C (protein phosphatase 6 catalytic subunit) is a protein-coding gene located on chromosome 9.
Serine/threonine-protein phosphatase 6 catalytic subunit is an enzyme that in humans is encoded by the PPP6C gene. PPP6C has been shown to interact with IGBP1.
The protein encoded by this gene is the catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. The N-terminal domain of this protein restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. During mitosis, PP6 regulates spindle positioning. PP6 down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. PP6 participates in the innate immune defense against viruses by desphosphorylating RIGI, an essential step that triggers RIGI-mediated signaling activation. PP6 also regulates innate immunity by acting as a negative regulator of the cGAS-STING pathway: it mediates dephosphorylation and inactivation of CGAS and STING1. CGAS dephosphorylation at 'Ser-435' impairs its ability to bind GTP, thereby inactivating it.
PPP6C is also known as PP6, PP6C.
Associated Diseases
- skin basal cell carcinoma
- carcinoma of liver and intrahepatic biliary tract
- superficial spreading melanoma
- pancreatic ductal adenocarcinoma
- acral lentiginous melanoma
- skin squamous cell carcinoma
