PPP4C
Description
The PPP4C (protein phosphatase 4 catalytic subunit) is a protein-coding gene located on chromosome 16.
Serine/threonine-protein phosphatase 4 catalytic subunit is an enzyme that in humans is encoded by the PPP4C gene.
Protein phosphatase 4 catalytic subunit (PP4C) is a key enzyme involved in various cellular processes including microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation, and cell migration. PP4C forms complexes with regulatory subunits, like PPP4R1, PPP4R2, and PPP4R3A, which contribute to its diverse functions. For instance, the PPP4C-PPP4R1 complex regulates HDAC3 dephosphorylation, while the PPP4C-PPP4R2-PPP4R3A complex specifically dephosphorylates gamma-H2AX, a crucial step in DNA double-strand break repair. PP4C also dephosphorylates NDEL1, negatively regulating CDK1 activity, and plays a vital role in DNA repair by catalyzing RPA2 dephosphorylation, facilitating RAD51 recruitment to chromatin.
PPP4C is also known as PP-X, PP4, PP4C, PPH3, PPP4, PPX.
