PPP1R3A
Description
The PPP1R3A (protein phosphatase 1 regulatory subunit 3A) is a protein-coding gene located on chromosome 7.
PPP1R3A is a gene that encodes for the enzyme protein phosphatase 1 regulatory subunit 3A. This enzyme, in its glycogen-associated form, is a heterodimer composed of a 37-kD catalytic subunit and a 124-kD targeting and regulatory subunit. This subunit binds to muscle glycogen with high affinity, enhancing dephosphorylation of glycogen-bound substrates for PP1, such as glycogen synthase and glycogen phosphorylase kinase. Phosphorylation at ser46 of the PP1G subunit in response to insulin increases PP1 activity, while phosphorylation at ser65 in response to adrenaline causes dissociation of the catalytic subunit from the G subunit and inhibits glycogen synthesis.
PPP1R3A is also known as GM, PP1G, PPP1R3.
