PPP1R10
Description
The PPP1R10 (protein phosphatase 1 regulatory subunit 10) is a protein-coding gene located on chromosome 6.
PPP1R10, also known as Serine/threonine-protein phosphatase 1 regulatory subunit 10, is an enzyme encoded by the PPP1R10 gene in humans. This gene is located within the major histocompatibility complex class I region on chromosome 6. PPP1R10 shares similarity with a rat protein that inhibits protein phosphatase-1 (PP1). This rat protein localizes to the nucleus and colocalizes with chromatin during specific phases of mitosis.
PPP1R10 acts as a scaffold protein, bringing together the components of the PTW/PP1 phosphatase complex. This complex plays a crucial role in regulating chromatin structure and cell cycle progression, particularly during the transition from mitosis to interphase. PPP1R10 facilitates the interaction between WDR82 and PPP1CA. It also functions as an inhibitor of PPP1CA and PPP1CC phosphatase activities, specifically inhibiting PPP1CA when phosphorylated. PPP1R10 has the ability to bind to mRNA, single-stranded DNA, and poly(A) and poly(G) homopolymers.
PPP1R10 is also known as CAT53, FB19, PNUTS, PP1R10, R111, p99.
Associated Diseases
- Alzheimer disease
- Parkinson disease
- multiple sclerosis
- lysosomal storage disease
- cancer
- breast cancer
- tuberculosis
