PPP1CC
Description
The PPP1CC (protein phosphatase 1 catalytic subunit gamma) is a protein-coding gene located on chromosome 12.
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit is an enzyme that in humans is encoded by the PPP1CC gene.
PPP1CC encodes a protein phosphatase that interacts with over 200 regulatory proteins to form highly specific holoenzymes. These holoenzymes dephosphorylate hundreds of biological targets, playing a crucial role in various cellular processes. PPP1CC is essential for cell division and is involved in the regulation of glycogen metabolism, muscle contractility, and protein synthesis. It dephosphorylates RPS6KB1, regulates ionic conductances, and contributes to long-term synaptic plasticity. PPP1CC is also involved in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. PPP1CC is a component of the PTW/PP1 phosphatase complex, which controls chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, PPP1CC determines the circadian period length by regulating the speed and rhythmicity of PER1 and PER2 phosphorylation. It may dephosphorylate CSNK1D and CSNK1E. Furthermore, PPP1CC dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, inactivating FOXP3 and rendering Treg cells functionally defective.
PPP1CC is also known as PP-1G, PP1C, PPP1G.
Associated Diseases
- Noonan syndrome
- esophageal cancer
- partial chromosome Y deletion
- male infertility with teratozoospermia due to single gene mutation
- spermatogenic failure 25
- spermatogenic failures 50
- spermatogenic failure 63
- spermatogenic failure 48
- spermatogenic failure, X-linked, 2
- spermatogenic failure 65
- spermatogenic failure, X-linked, 3
- spermatogenic failure 39
- spermatogenic failure 40
- spermatogenic failure 11
- spermatogenic failure 10
- spermatogenic failure 61
- spermatogenic failure 74
- spermatogenic failure 73
- spermatogenic failure 72
