PPME1
Description
The PPME1 (protein phosphatase methylesterase 1) is a protein-coding gene located on chromosome 11.
PPME1, also known as PME-1, is an enzyme responsible for catalyzing the removal of methyl groups from proteins that have been reversibly carboxymethylated. This process is formally known as demethylation. The enzyme's systematic name is (phosphatase 2A protein)-leucine ester acylhydrolase, and it is classified under EC 3.1.1.89.
PPME1 removes methyl groups from proteins that have been reversibly modified by the addition of a carboxymethyl group. This demethylation activity has been observed in vitro for the proteins PPP2CB and PPP2CA. Interestingly, PPME1 binding to PPP2CA displaces the manganese ion, rendering the enzyme inactive.
PPME1 is also known as ABDH19, PME-1.
Associated Diseases
- hypertriglyceridemia 2
- cholesterol-ester transfer protein deficiency
- hypoalphalipoproteinemia, primary, 1
- hyperlipidemia due to hepatic triglyceride lipase deficiency
- homozygous familial hypercholesterolemia
- cancer
- pachyonychia congenita
- glioblastoma
- malignant glioma
