PPM1B
Description
The PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B) is a protein-coding gene located on chromosome 2.
PPM1B is a protein phosphatase enzyme encoded by the PPM1B gene in humans. It belongs to the PP2C family of Ser/Thr protein phosphatases, which are known to negatively regulate cell stress response pathways. PPM1B dephosphorylates cyclin-dependent kinases (CDKs), potentially playing a role in cell cycle control. Overexpression of PPM1B can lead to cell growth arrest or cell death. Multiple transcript variants encoding different isoforms exist due to alternative splicing. PPM1B has been shown to interact with CDK2, CDK6, CHUK, IKBKG, IKK2, MAP3K7, and PPARγ.
PPM1B is an enzyme with broad substrate specificity. It dephosphorylates CDK2 and CDK6 in vitro, as well as PRKAA1 and PRKAA2. PPM1B also plays a role in regulating antiviral signaling by dephosphorylating TBK1 at Ser-172, inhibiting its activity. Additionally, PPM1B is involved in terminating TNF-alpha-mediated NF-kappa-B activation by dephosphorylating and inactivating IKBKB/IKKB.
PPM1B is also known as PP2C-beta, PP2C-beta-X, PP2CB, PP2CBETA, PPC2BETAX.
