PPIL3

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Description

The PPIL3 (peptidylprolyl isomerase like 3) is a protein-coding gene located on chromosome 2.

PPIL3 is an enzyme encoded by the PPIL3 gene in humans. It belongs to the cyclophilin family, which catalyzes the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. Cyclophilins are thought to act as catalysts or molecular chaperones in protein folding events. Multiple transcript variants exist, some of which encode different isoforms.

PPIL3 is also known as CYPJ.

Associated Diseases

• cholesterol-ester transfer protein deficiency
• hypertriglyceridemia 2
• thyroid hormone metabolism, abnormal, 2
• sitosterolemia
• homozygous familial hypercholesterolemia
• hyperlipidemia due to hepatic triglyceride lipase deficiency
• hypercholesterolemia, autosomal dominant, 3
• hypercholesterolemia, autosomal dominant, type B
• familial apolipoprotein C-II deficiency
• cancer
• colorectal cancer