PPIL2
Description
The PPIL2 (peptidylprolyl isomerase like 2) is a protein-coding gene located on chromosome 22.
PPIL2 (Peptidyl-prolyl cis-trans isomerase-like 2) is a human enzyme encoded by the PPIL2 gene. It belongs to the cyclophilin family, a group of highly conserved proteins involved in protein folding, immune suppression, and viral infection. PPIL2 interacts with the proteinase inhibitor eglin c and resides in the nucleus. The gene produces multiple transcript variants leading to different protein isoforms.
PPIL2 acts as an E3 ubiquitin ligase, promoting the attachment of ubiquitin chains to target proteins. This 'Lys-48'-linked polyubiquitination marks proteins for degradation by the proteasome. PPIL2 also functions as a chaperone, facilitating the transport of proteins like BSG/Basigin to the cell membrane. Interestingly, despite being a member of the cyclophilin family, PPIL2 lacks peptidyl-prolyl cis-trans isomerase activity. As part of the minor spliceosome, PPIL2 participates in the splicing of U12-type introns in pre-mRNAs.
PPIL2 is also known as CYC4, CYP60, Cyp-60, UBOX7, hCyP-60.
