PPBP
Description
The PPBP (pro-platelet basic protein) is a protein-coding gene located on chromosome 4.
PPBP, or Pro-Platelet basic protein, is a small cytokine belonging to the CXC chemokine family. It is released from platelets following activation and plays a role in various cellular processes. These processes include promoting cell growth, stimulating the production of extracellular matrix, regulating glucose metabolism, and activating plasminogen, which is involved in breaking down blood clots.
PPBP (also known as LA-PF4) stimulates various cellular processes, including DNA synthesis, mitosis, glycolysis, cAMP accumulation, prostaglandin E2 secretion, and the production of hyaluronic acid and sulfated glycosaminoglycans. It also promotes the formation and release of plasminogen activator by synovial cells. Other isoforms of PPBP, such as NAP-2, act as chemoattractants and activators for neutrophils, binding to receptors CXCR1 and CXCR2. Additionally, isoforms like TC-1 and TC-2 exhibit antibacterial properties, while CTAP-III(1-81) is a more potent form of CTAP-III that can desensitize chemokine-induced neutrophil activation. These diverse functions highlight the multifaceted roles of PPBP in cellular signaling and immune responses.
PPBP is also known as B-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1.
