PON3
Description
The PON3 (paraoxonase 3) is a protein-coding gene located on chromosome 7.
Paraoxonase 3, also known as PON3, is a protein encoded by the PON3 gene in humans. It belongs to the paraoxonase family and is located in a cluster on chromosome 7 with the other two family members. PON3 is secreted into the bloodstream and associates with high-density lipoprotein (HDL). It can rapidly hydrolyze lactones and inhibit the oxidation of low-density lipoprotein (LDL), a function believed to slow the initiation and progression of atherosclerosis. Several alternatively spliced variants have been described, encoding different protein isoforms, but only one has been fully characterized.
PON3 is also known as -.
