POLL
Description
The POLL (DNA polymerase lambda) is a protein-coding gene located on chromosome 10.
POLL encodes DNA polymerase lambda (Pol λ), an enzyme found in all eukaryotes. It is a member of the X family of DNA polymerases and is involved in resynthesizing missing nucleotides during non-homologous end joining (NHEJ), a major pathway for repairing DNA double-strand breaks (DSBs) in higher eukaryotes. Pol λ stabilizes the two ends of a DSB due to its extensive contacts with the 5' phosphate of the downstream DNA strand, making it uniquely suited for NHEJ.
POLL, also known as DNA polymerase lambda, is involved in multiple DNA repair pathways, including base excision repair (BER) and double-strand break (DSB) repair via non-homologous end joining (NHEJ) and homologous recombination. It plays a role in filling gaps during NHEJ and BER. POLL possesses both template-dependent and template-independent (terminal transferase) DNA polymerase activities, as well as 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. Its interactions with PCNA, PAXX, XRCC4, and NHEJ1/XLF enhance its recruitment to DSBs and stimulate its end-filling activity.
POLL is also known as BETAN, POLKAPPA.
