POLE
Description
The pole gene, also known as TPX2, plays a pivotal role in regulating cell division, particularly during mitosis. This gene encodes a protein that is essential for the proper formation and function of the mitotic spindle, a structure that separates chromosomes during cell division. Mutations in the pole gene can lead to severe developmental abnormalities and even cancer. The protein produced by this gene is involved in various crucial steps of mitosis, including the assembly of the mitotic spindle, the attachment of chromosomes to the spindle, and the segregation of chromosomes to daughter cells. Understanding the role of the pole gene and its associated proteins is essential for gaining a deeper insight into the intricacies of cell division and its potential implications for human health.
Associated Diseases
Did you know?
The pole gene was first discovered in a genetic screen for mutations that affect cell division in the fruit fly Drosophila melanogaster.
