POLD4
Description
The POLD4 (DNA polymerase delta 4, accessory subunit) is a protein-coding gene located on chromosome 11.
DNA polymerase delta subunit 4, also known as DNA polymerase delta subunit p12, is a protein that in humans is encoded by the POLD4 gene. It is a component of the DNA polymerase delta complex.
POLD4, as part of the DNA polymerase delta complex (Pol-delta4), contributes to accurate DNA replication and repair. It enhances DNA synthesis speed while reducing error rates by influencing the activity of POLD1, the polymerase and proofreading enzyme within the complex. Pol-delta4 participates in processing Okazaki fragments through both the short flap pathway and a nick translation system. During replication stress, POLD4 is crucial for repairing broken replication forks via break-induced replication (BIR), which can lead to segmental genomic duplications. POLD4 also assists in translesion synthesis (TLS) of damaged DNA templates containing O6-methylguanine or abasic sites. Degradation of POLD4 in response to DNA damage is essential for halting replication fork progression and promoting cell survival.
POLD4 is also known as POLDS, p12.
Associated Diseases
- adult acute lymphoblastic leukemia
- breast cancer
- ovarian cancer
- pancreatic ductal adenocarcinoma
- extranodal nasal NK/T cell lymphoma
- beta-thalassemia major
