POLB

Description

The POLB (DNA polymerase beta) is a protein-coding gene located on chromosome 8.

POLB may refer to:

POLB is a repair polymerase that plays a key role in base-excision repair (BER). During BER, damaged bases are excised by DNA glycosylases, creating abasic (AP) sites. An AP endonuclease nicks the DNA backbone at the AP site, and POLB removes the 5'-deoxyribose-phosphate (5'-dRP) from the preincised AP site, acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase). POLB then uses its DNA polymerase activity to add one nucleotide to the 3' end of the resulting single-nucleotide gap, completing the BER process. POLB performs 'gap-filling' DNA synthesis in a distributive manner, adding nucleotides one at a time rather than processively like other DNA polymerases. POLB can also cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase.

POLB is also known as -.

Associated Diseases

• ovarian cancer
• endometrial cancer
• autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency
• autosomal systemic lupus erythematosus type 16
• immunodeficiency 25
• autoimmune lymphoproliferative syndrome type 2A
• immunodeficiency 72 with autoinflammation
• autoimmune lymphoproliferative syndrome type 2B
• autoinflammatory syndrome with immunodeficiency
• immunodeficiency 78 with autoimmunity and developmental delay
• systemic lupus erythematosus
• autoimmune lymphoproliferative syndrome
• immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome