POGZ : pogo transposable element derived with ZNF domain
Description
The POGZ (pogo transposable element derived with ZNF domain) is a protein-coding gene located on chromosome 1.
The POGZ gene provides instructions for making a protein found within the cell nucleus. This protein, known as POGZ, is a zinc finger protein containing regions that bind to zinc ions and other molecules. POGZ binds to chromatin, the complex of DNA and proteins that packages DNA into chromosomes. This binding is crucial for chromatin remodeling, a process that alters the structure of chromatin, ultimately affecting gene expression. When DNA is tightly packed, gene expression is lower, while loose packaging allows for higher expression. POGZ's role in regulating gene expression is thought to be essential for brain development, although its precise function in the brain remains unclear.
The POGZ protein plays a vital role in regulating the cell cycle, particularly during mitosis. It participates in the assembly of kinetochores, the structures that attach chromosomes to microtubules during cell division, and helps maintain the cohesion of sister chromatids. Through its interaction with CBX5, POGZ influences the segregation of chromosomes during mitosis by modulating the activation of aurora kinase B (AURKB) and facilitating the detachment of AURKB and CBX5 from chromosome arms. Furthermore, POGZ promotes the repair of double-strand breaks in DNA through the homologous recombination pathway.
POGZ is also known as MRD37, WHSUS, ZNF280E, ZNF635, ZNF635m.
