PNRC2
Description
The PNRC2 (proline rich nuclear receptor coactivator 2) is a protein-coding gene located on chromosome 1.
Proline-rich nuclear receptor coactivator 2 is a protein that in humans is encoded by the PNRC2 gene.
PNRC2 is involved in nonsense-mediated mRNA decay (NMD) by bridging the mRNA decapping complex and the NMD machinery. It may target the NMD machinery to the P-body and recruit the decapping machinery to aberrant mRNAs. PNRC2 is essential for UPF1/RENT1 localization to the P-body. It plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when bound to the 5' UTR of target mRNAs. This interaction recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. PNRC2 also acts as a nuclear receptor coactivator. It may play a role in controlling the energy balance between energy storage and energy expenditure.
PNRC2 is also known as -.
