PNCK

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Description

The PNCK (pregnancy up-regulated nonubiquitous CaM kinase) is a protein-coding gene located on chromosome X.

PNCK is a calcium/calmodulin-dependent protein kinase that participates in a proposed calcium-triggered signaling cascade. It has been shown to phosphorylate CREB1 and SYN1/synapsin I in vitro, and is believed to activate CAMK1.

PNCK is also known as BSTK3, CaMK1b.

Associated Diseases

• creatine transporter deficiency
• cerebral creatine deficiency syndrome
• nonpapillary renal cell carcinoma
• schizophrenia 15
• Phelan-McDermid syndrome
• cancer
• breast cancer
• colorectal cancer
• Bartsocas-Papas syndrome 1
• cervical squamous intraepithelial neoplasia