PMS1
Description
The PMS1 (PMS1 homolog 1, mismatch repair system component) is a protein-coding gene located on chromosome 2.
PMS1 protein homolog 1 is a protein that in humans is encoded by the PMS1 gene. The protein encoded by this gene was identified by its homology to a yeast protein involved in DNA mismatch repair. A role for this protein in mismatch repair has not been proven. However, the protein forms heterodimers with MLH1, a DNA mismatch repair protein, and some cases of hereditary nonpolyposis colorectal cancer have been found to have mutations in this gene.
The PMS1 protein is likely involved in repairing mismatches in DNA.
PMS1 is also known as HNPCC3, MLH2, PMSL1, hPMS1.
