PMEPA1
Description
The PMEPA1 (prostate transmembrane protein, androgen induced 1) is a protein-coding gene located on chromosome 20.
PMEPA1 acts as a negative regulator of TGF-beta signaling, potentially influencing cell processes like proliferation, differentiation, apoptosis, movement, extracellular matrix production, and immune suppression. In the typical TGF-beta pathway, ZFYVE9/SARA directs SMAD2 and SMAD3 (intracellular signal carriers and transcription regulators) to the TGF-beta receptor. Following receptor phosphorylation, SMAD2 and SMAD3 create a complex with SMAD4, which travels to the nucleus to regulate gene expression. PMEPA1 interacts with SMAD2 and SMAD3, potentially competing with ZFYVE9 and SMAD4 to block signal propagation. PMEPA1 also participates in reducing androgen receptor (AR) activity, promoting its degradation through ubiquitination and the proteasome, likely by associating with NEDD4.
PMEPA1 is also known as STAG1, TMEPAI.
