PLXNB2
Description
The PLXNB2 (plexin B2) is a protein-coding gene located on chromosome 22.
Plexin-B2 is a protein encoded by the PLXNB2 gene in humans. It belongs to the B class of plexins, which are transmembrane receptors involved in axon guidance and cell migration in response to semaphorins. Plexin-B2 has been shown to interact with ARHGEF11.
Plexin-B2 is a cell surface receptor that binds to the semaphorins SEMA4C, SEMA4D, and SEMA4G, playing a crucial role in cell-cell signaling. It contributes to glutamatergic synapse development and is essential for SEMA4A-mediated excitatory synapse development. Binding to class 4 semaphorins activates RHOA and leads to phosphorylation of ERBB2 at tyrosine 1248. Plexin-B2 is vital for normal neuronal cell differentiation and migration during brain corticogenesis and is required for proper embryonic brain development. It regulates the migration of cerebellar granule cells in the developing brain. Plexin-B2 also participates in RHOA activation, which in turn modifies the actin cytoskeleton. This protein is involved in axon guidance, invasive growth, and cell migration. Plexin-B2 may also modulate the activity of RAC1 and CDC42.
PLXNB2 is also known as MM1, Nbla00445, PLEXB2, dJ402G11.3, lncFAL.
